Procyanidin C1 (PCC1) is a natural polyphenol found within the procyanidin family, a group of dozens of compounds found in grape seed extract. In the procyanidin family, PCC1 is the key compound that is uniquely effective at clearing senescent cells—often called "Zombie cells." These are toxic, aged, and damaged cells that linger in the body and secret toxins that drive systemic inflammation and accelerate aging. Current literature points to PCC1 as being the most potent naturally-occuring senolytic compound that we have identified.

Standard grape seed extracts typically contain only 0.6% PCC1 and are notoriously difficult for the body to absorb. Lonvi has pioneered an extraction method that concentrates active PCC1 to 20% (30x the standard strength). Lonvi has also engineered a phytosomal shield that improves absorption by 6x–10x. The result? A single regimen of Lonvi PCC1 provides the equivalent PCC1 absorption of consuming one metric ton of grapes.

In human studies, Lonvi PCC1 significantly reduced toxic inflammatory signals. Key biomarkers, including SASP factors (IL-6 and IL-8) and senescent markers (p21 and SA-β-gal), were lowered by 25–75%. These markers are the primary drivers of chronic systemic inflammation and biological aging. No other natural compound has demonstrated a comparable reduction in these inflammatory signals. Furthermore, groundbreaking research in mice showed that PCC1 extended the remaining lifespan of aged subjects by over 60%.

Unlike other synthetic or natural senolytics, PCC1 is a plant-derived polyphenol with an strong safety and tolerance profile. Research published in leading longevity journals indicates that PCC1 produces no toxicity in vital organs. Instead, animal studies have shown it may actually restore function in the brain, kidneys, intestines, and liver. Human studies confirm that Lonvi’s PCC1 high-potency formulation is remarkably well-tolerated, with participants reporting little to no negative side effects.