Procyanidin C1 (PCC1) is a natural polyphenol found within the procyanidin family, a group of dozens of compounds found most potently in grape seed, but also other plants (apples, cinnamon). Among the procyanidin molecules, PCC1 is the key compound that is extraordinarily effective at clearing senescent cells—often called "Zombie cells." These are toxic, aged, and damaged cells that secret toxins that cause systemic inflammation and accelerate aging. Current literature points to PCC1 as being the most potent natural senolytic compound that is known to science.

Standard grape seed or apple extracts typically contain large amounts of procyanidins, but only 0.1-0.6% PCC1. PCC1 is also notoriously difficult for the body to absorb. Lonvi has pioneered an extraction method that concentrates active PCC1 up to 20% (30x the standard potency). Lonvi has also engineered a phytosomal shield that improves absorption by 6x–10x. The result? A single regimen of Lonvi PCC1 is the equivalent of consuming three metric tons of grapes, in PCC1 terms.

In human studies, Lonvi PCC1 significantly reduced toxic inflammatory signals. Key biomarkers, including SASP factors (IL-6 and IL-8) and senescent markers (p21 and SA-β-gal), were lowered by 25–75%. These markers are the primary drivers of chronic systemic inflammation and biological aging. No other natural compound has demonstrated a comparable reduction in these inflammatory signals. Furthermore, groundbreaking research in mice showed that PCC1 extended the remaining lifespan of aged subjects by over 60%.

Unlike other synthetic or natural senolytics, PCC1 is a plant-derived polyphenol with an strong safety and tolerance profile. Research published in leading longevity journals indicates that PCC1 produces no toxicity in vital organs. Instead, animal studies have shown it may actually restore function in the brain, kidneys, intestines, and liver. Human studies confirm that Lonvi’s PCC1 high-potency formulation is remarkably well-tolerated, with participants reporting little to no negative side effects.

As always, when taking new supplements, we urge you to consult your healthcare professional.

Do not take if pregnant, nursing, or under 18 years of age. Keep out of reach of children.

Take 3 pills (1 sachet) each day for three consecutive days. It is recommended to take pills without food, and separate 3-4 hours from any large meal. If you don't tolerate polyphenols well, it is OK to take pills with a small carbohydrate snack (like crackers or crisps) or some fat (like a tablespoon of olive oil), but no protein.

Repeat this protocol once a month, or twice a month (once every two weeks) if you have significant chronic inflammation.

During the 3-day protocol, we recommend stopping all non-essential supplement at least 1 day before, specifically NAC, GSH, Alpha-Lipoic, Vitamin C, Vitamin E, CoQ10, and PQQ. Anti-oxidant supplements have a protective effect on cells, including protecting toxic senescent cells. The PCC1 will therefore not be able to remove the senescent cells.

Please consult your physician if you have a medical condition or are taking medication. If you are taking medication, please see our Application Guidelines PDF for full clinical drug interactions.

Our summary Pre-administration Checklist is as follows:

1. Antioxidant Cessation: Stop NAC, GSH, High-dose Vit C, CoQ10, Vit E (≥ 24h).
2. Statin Check: Confirm specific statin type. DO NOT TAKE PCC1, if on high-dose Atorvastatin, Simvastatin, or Lovastatin.
3. Medication Screening: Confirm no use of Tacrolimus, Cyclosporine, Warfarin.
4. Chemotherapy Status: No Bortezomib; not on infusion day.
5. Nutrient Timing: Protein/FSMP separated by 4 hours.
6. Hydration Plan: Daily high-volume water intake established.

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Shipping times will vary by location. Generally, shipping will be 12-15 business days.

We currently ship to the following locations:
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Asia: Hong Kong, New Zealand, Singapore