Biomarker Research on PCC1
Impact of Procyanidin C1 on Distinct Senescent Cells and Associated Biomarkers
| Cells | Dosages | Mechanisms (index) | References |
|---|---|---|---|
| 661W, BV2, ARPE-19, HRMEC Cells | 50-200 μM |
↓: SA-β-GAL, p16/p21, IL-6, IL-1β, TNF-α, VEGF-A
|
(Liu et al., 2024) |
| Primary Pulmonary Fibroblasts, PSC27, WI-38, HUVEC, MSC Cells | 100-200 μM |
↓: SA-β-GAL, CXCL8, IL-1α
↑: NOXA, PUMA, ROS, MitoSOX
|
(Xu et al., 2021) |
| Primary Pulmonary Myofibroblasts | 100 μM |
↓: SA-β-GAL, p16, p21, p53, ECM Deposition, Mitochondrial Membrane Potential (ΔΨm)
↑: Mitochondrial ROS levels
|
(Shao, M et al., 2024) |
| RAW264.7, BMDMs | 25 μg/mL, 50 μg/mL, 100 μg/mL |
↓: NO, TNF-α, IL-6, PGE₂, CD80, CD86, MHC II, iNOS, COX-2
|
(Byun, E. B et al., 2013) |
| Mouse 3T3-L1 Preadipocytes | 25 μM |
↓: Glycerol Release
↑: TG, aP2/PPARγ, p-AKT, NO, GLUT4
|
(Sun, P et al., 2019) |
| HT22 Cells | 5, 10 μM |
↓: p-ERK1/2, p-p38, ROS, Annexin V⁺
↑: DPPH, Nrf2, HO-1
|
(Song, J. H et al., 2019) |
| Microglia | 50 μg/mL |
↓: ROS, MDA, TNF-α, IL-1β, BAX
↑: GSH, SOD, Bcl-2, IL-4, IL-10
|
(Duan, J et al., 2022) |
| PC12 Cells | 5 μM |
↓: ROS, MDA
↑: Nrf2, HO-1, NQO1
|
(Chen, J et al., 2022) |
Impact of Procyanidin C1 on Aging Animal Models and Associated Biomarkers
| Models | Dosages | Mechanisms (index) | References |
|---|---|---|---|
| C57BL/6J Mice | 8 mg/kg |
↓: SA-β-GAL, p16/p21, IL-6, IL-1β, TNF-α, Apoe, Trem2, Spp1
|
(Liu et al., 2024) |
| NOD-SCID Mice | 20 mg/kg |
↓: SA-β-GAL, IL-6, CXCL8, WNT16B, Tumor Volume
↑: Caspase-3
|
(Xu et al., 2021) |
| BALB/c Nude Mice | 20 mg/kg |
↓: miR-501-3p, Ki67+, p-Rb, MMP-9, N-cadherin
|
(Lv, J. L et al., 2024) |
| 40 mg/kg |
↑: HIGD1A
|
||
| C57BL | 8 mg/kg |
↓: SA-β-GAL, p16/p21, IL-6, IL-1β, TNF-α, Apoe, Trem2, Spp1
|
(Liu et al., 2024) |
| 20 mg/kg |
↓: SA-β-GAL, IL-6, CCL2, WNT16B, MCP-1
↑: NOXA, PUMA, Caspase-3, Median Survival, Walking Speed, Balance Performance
|
(Xu et al., 2021) | |
| Zebrafish Larvae | 25 μM |
↓: ROS, MDA, GSH-Px, CAT
↑: Nrf2, HO-1, NQO1, SOD
|
(Chen, J et al., 2022) |
| 5×FAD Transgenic Mice | 5 mg/kg |
↓: Aβ1-42, Tau, p-Tau (ser396, 235), AChE, Bax, P21, P16, P53, TNF-α, IL-1β, MDA, NLRP3
↑: BDNF, Ki67, NeuN, DCX, Bcl-2, IL-4, IL-10, GSH, SOD, PI3K/AKT
|
(Duan, J et al., 2022) |